BIOL 2201 Lecture Notes - Lecture 3: Hydrolysis, Alpha Helix, Covalent Bond

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Polypeptide chain: amino acids are joined by peptide bonds. The amino acid that is closer to n-terminus is amino1 and goes all the way to c- terminus. Genetic code on the dna gives you the primary structure of it. Reading frame that is used for translation. (cid:271)ased o(cid:374) the rotatio(cid:374) they (cid:272)a(cid:374) for(cid:373) (cid:271)o(cid:374)ds like hydroge(cid:374) (cid:271)o(cid:374)ds, that (cid:373)ight effe(cid:272)t the shape it is taking. Polar/charged amino acids (hydrophilic) or nonpolar/no charged amino acids (hydrophobic). Polar and non polar are important for protein folding. The alpha helix: stabilized by hydrogen bonds between nearby residues. The beta sheet: discovered in silk. stabilized by hydrogen between adjacent segments that may not be nearby. The side chains are not involved in forming the helix structure. Some side chains are involved to form coil structure. Beta sheet: the formation of the bond not between side chains but between amino acids and carboxyl group.

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