NEUR 3204 Lecture Notes - Lecture 5: Tyrosine Hydroxylase, Substantia Nigra, Essential Amino Acid

• School: Carleton University
• Department: Neuroscience
• Course: NEUR 3204
• Professor: Matthew Holahan

Document Summary

Lecture 5: da (cid:894)(cid:449)hat (cid:449)e"ll (cid:272)o(cid:448)er toda(cid:455). Epi usuall(cid:455) (cid:271)i(cid:374)ds sa(cid:373)e re(cid:272)eptors as ne, i(cid:374) the peripheral s(cid:455)ste(cid:373): da is the precursor molecule for ne, so any nerve terminals that da in them convert any free da to ne. Once those nt are synthesized free float for a moment, and then they are released, so if you get this extra da it will turn into ne. Tyrosine= essential amino acid, you get it from your diet. Dopa is an amino acid sequence synthesized by cell bodies. Th- is the rate limiting factor, and is synthesized in the cell body too: remember the highlighted parts for exam. Also, dopa (l-dopa) is used as a treatment for. Also drug addicts who use a lot of da may have a deficiency. Tyrosine is an essential amino acid, they are brought into terminals not necessarily the cell bodies. If (cid:455)ou"re (cid:374)ot (cid:373)aki(cid:374)g a lot of da, (cid:455)ou"re (cid:374)ot (cid:373)aki(cid:374)g a lot of ne either.