NEUR 3304 Lecture Notes - Lecture 7: Allostatic Load, Glucocorticoid Receptor, Adrenal Medulla

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Can have fatal consequences, even when stakes are low. Has been seen in many sporting events where increased cardiovascular deaths have been found. 1996 netherlands soccer team were eliminated from championship and cardiac arrest/stroke increased by 50% Increase was not found in dutch males/females, or females in france. Similarly, after the loss in the super bowl, increase in heart attacks and strokes for 2 weeks: after a win, there was a decrease for the same time period and county. Human stress stems from conquest, war, famine, but there is better access to shelter and medical services. Wear and tear of stress = early death, compromised reproduction. Disruption to homeostasis requires energy to restore equilibrium. Energy goes to growth, cell maintenance, immune function, reproduction, thermogenesis. During energy shortages, processes that are not required for survival, are suppressed and immune function is decreased. If demands are still higher than available, a person is stressed and survival is compromised.

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