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Class Notes at Carleton University (page 1260)

BIOL 2005 Lecture Notes - Thymocyte, Apoptosis, Clonal Deletion

IMMUNOLOGY T CELL SELECTION AND CENTRAL TOLERANCE Tolerance-state of the immune system characterized by unresponsiveness to a particular antigen - ability to distinguish self from non self (unique...

Biology
BIOL 2005
Elizabeth Nisbet
BIOL 2005 Lecture Notes - Thymocyte, T-Cell Receptor, Clonal Deletion

T CELL TOLERANCE AND DEVELOPMENT TOLERANCE – unresponsiveness to a particular ag (usually self) self-tolerance is learned by developing immune system FREEMARTIN condition in twin catt...

Biology
BIOL 2005
Elizabeth Nisbet
BIOL 2005 Lecture Notes - Interleukin 10, Immunoglobulin A, Cytokine

T CELL TOLERANCE Immune activation vs. tolerance is CIRCUMSTANCE driven Janeway: immune system responds to antigen + presence of PAMP/PRR int. no PAMP/PRR interaction  tolerance Matz...

Biology
BIOL 2005
Elizabeth Nisbet
BIOL 2005 Lecture Notes - Cytokine, Interleukin 2, Cd24

IMMUNOLOGY T CELL TOLERANCE -Generation of diversity is a stochastic post germ line encoded event. -The ability to discern btw harmful and innocuous antigens is learned in the neonatal period ...

Biology
BIOL 2005
Elizabeth Nisbet
BIOL 2005 Lecture Notes - Antigen Processing, Hyper Igm Syndrome, Phos

IMMUNODEFICIENCY 150 known diseases 2 mechanisms of hypogammaglobulinemia  2 clinical manifestations 1) poor maturation of B cells: X-Linked Agammaglobulinemia prototypic antibody deficiency disease anti...

Biology
BIOL 2005
Elizabeth Nisbet
BIOL 2005 Lecture Notes - Exocytosis, Death Domain, Superoxide

IMMUNOLOGY CD8 CYTOLYTIC T LYMPHOCYTES (CTL) -CTLS lyse target cells that display processed foreign antigens bound to MHC molecules. -free virus and bacteria cant trigger CTLs -pathogens repli...

Biology
BIOL 2005
Elizabeth Nisbet
BIOL 1104 Lecture Notes - Apoptosis, Stromal Cell, Peripheral Tolerance

Outline of Lecture 11 T Cell Selection and Central Tolerance I. Tolerance defined A) Freemartin cows indicate that self tolerance is learned by developing immune system B) Neonatal t...

Biology
BIOL 1104
Tamy Superle
BIOL 2005 Lecture Notes - Rheumatoid Arthritis, Multiple Myeloma, Thymus

IMMUNE SYSTEM- protects host from diverse microorganisms and products -responds to anything perceived as foreign -attacking “self” = autoimmune disease Pathogens (small...

Biology
BIOL 2005
Elizabeth Nisbet
BIOL 1104 Lecture Notes - Cytokine, Wild Type, Cd74

T-CELL ANTIGEN RECOGNITION B and T cells are morphologically identical Claman studies – BOTH T and B cells are necessary for antibody response to antigen T cells obey CLONAL SELECTION also T cells don’t s...

Biology
BIOL 1104
Tamy Superle
BIOL 2005 Lecture Notes - Interleukin 4, T Helper Cell, Glycolipid

NATURAL KILLER CELLS part of innate immunity; no prior exposure is necessary anti viral, anti-tumor, transplant rejection, materno-fetal interaction roles protection during T-cell priming period ...

Biology
BIOL 2005
Elizabeth Nisbet
BIOL 1104 Lecture Notes - Immunoglobulin G, Nadph Oxidase, Superoxide

Outline of Lecture 06 Phagocytic Cells, Innate Immunity, and Host Defense *** Innate Immunity: Definition, Activation, Receptors I. Innate versus Adaptive Immunity Rehash from previous lectures I...

Biology
BIOL 1104
Tamy Superle
BIOL 2005 Lecture Notes - Ctla-4, Chemokine, T Helper Cell

LYMPHOID ORGANS highly localized microenvironments are structural basis of immune response lymphocyte specificity is quite rare, as is their dispersement throughout the body soln: highly orchestrated movements of...

Biology
BIOL 2005
Elizabeth Nisbet
BIOL 1104 Lecture Notes - Frameshift Mutation, Septic Shock, Leucine

Innate Immunity (Principles, Patterns, Receptor Signaling) L2/p.1 Innate Immunity-prepared to mount a fast, stereotyped defense against attack (rapid, general) Adaptive Immunuity-specific, learned, response to a s...

Biology
BIOL 1104
Tamy Superle
BIOL 1104 Lecture Notes - Organic Compound, Antibody, Antigen

INTRO – immune system to protect from: microorganisms (parasites, fungi, bacteria, viruses) antigen recognition - antibodies (B-cells), T-cell receptors - ANY or...

Biology
BIOL 1104
Tamy Superle
BIOL 1103 Lecture Notes - Ctla-4, Autocrine Signalling, Cd28

LYMPHOCYTE ACTIVATION all immune system responses begin with NAÏVE T CELL ACTIVATION features of T-cell activation that are distinct from other receptor-ligand processes requires MHC-presentation small pro...

Biology
BIOL 1103
Tamy Superle

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