BIOL 206 Lecture 13: Lecture 13
7 Mar 2016
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Document Summary
Understand the relevance of gene control in health and disease. Gene expression must be regulated in several dimensions. At different stages of life cycles, different genes to be on or off. Spatial regulation allows embryo, for example, to be divided into different regions that will give rise to a head, internal organs, abdomen, etc. Difference in strength of gene expression (abundance in one area vs another) has important functional consequences. Regulate access to the promoter region and control expression. Promoter sequence (tata box) is located 25 to 25 base pairs upstream of the transcription site. Proteins that bind to specific regulatory sites on the dna. Regulation of gene expression by small rna molecules. Binds to mrna and blocks ribosome from attaching to mrna. Regulation can occur at many places during transcription, translation, or after translation. Environment signals influence turning off and on of genes. By binding dna, regulatory proteins can block or facilitate the binding of rna polymerase and subsequent.
