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BIOL 200 (63)
Mary Silas (53)
Lecture

Microorganisms Cause DIsease

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Department
Biology
Course
BIOL 200
Professor
Mary Silas
Semester
Fall

Description
Pathogenesis: How Microorganisms Cause Disease  Damage or destroy host cells - e.g. HIV, Salmonella o Organism is taken up by epithelial cells in the intestine  HOST SPECIFIC: ligand on pathogen must fit onto receptor proteins on host  Some hosts are more susceptible than others because proteins depend on gene coding o Destroy brush border of microvilli o Host creates a ruffled surface / Invaded cells detach from intestinal wall, creating inflamed lesions / Secretion of large amounts of watery fluid into the lumen of the gut → diarrhoea  Produce toxic waste - e.g. Vibrio cholerae o Are harmless but produce harmful "exotoxins" - toxins released from the cell o Causes loss of chloride and hydrogencarbonate ions from the intestinal cells o Osmotic loss of up to 10 litres of water per day o Impaired absorption of water and salt from the gut o This explains severe watery diarrhoea and death from dehydration  Body's own immune response to the presence of microorganisms which produce the symptom o e.g. Mycobacterium tuberculosis o Body tries do destroy the invading bacteria o This causes inflammation and damage to the surrounding cells occur o Lesions may become hard or spongy, leaving "holes" in the lungs, sometimes damaging blood vessels  Some bacteria will cause all of the 3 ways above; Some require a large number of bacteria for a disease; Some will only a few number of
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