CHEM 271 Lecture Notes - Lecture 10: Table Tennis, Monoamine Oxidase, Salt Metathesis Reaction
13 Dec 2016
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You should know what is meant by sequential and double displacement mechanisms for reactions with more than one substrate. Sequential: all substrates must bind to the enzyme before any product is released and can either be ordered (binding in specific order) or random. Nadh as substrate are sequential: in a bisubstrate reaction, a ternary complex of the enzyme and both substrates forms, two types: ordered, in which the substrates must bind to the enzyme in a defined sequence, and random. Double displacement (ping pong): one or more products are released before all substrates bind to enzyme. Main example is reactions that move amino group between amino acids and. It consists of a substituted enzyme intermediate (enzyme temporarily modified). alpha-ketoacids. You should know the difference between irreversible and reversible inhibitors. Irreversible: dissociate very slowly since they are tightly bound to the enzyme (either covalently or non-covalently).
