PSYC 340 Lecture Notes - Lecture 3: Delusional Disorder, Antipsychotic, Temporal Lobe
19 Sep 2018
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Some correlation with clinical outcome and antipsychotic treatment. Not all people with sz show this characteristic and the medication taken to treat. Eg premkumar et al (2006), molina et al (2004) prefrontal cortical grey matter. First-episode (fe) patients vs. controls: no differences. Fe patients vs. chronic: shrinkage over time. Redu(cid:272)ed te(cid:373)poral (cid:448)olu(cid:373)e i(cid:374) fe"s, (cid:271)ut (cid:374)o further redu(cid:272)tio(cid:374)s i(cid:374) (cid:272)hro(cid:374)i(cid:272) patie(cid:374)ts. A large scale study looking specifically at the hippocampus (velakoulis et al, Reduced left hippocampal (hc) volume in fe patients. Reduced bilateral hc volume in chronic patients. Normal hc volume in high-risk subjects, including those who went on to develop schizophrenia. Frontal and temporal lobe changes follow different timelines. Mri studies of schizophrenia show sometimes conflicting results. Local vs. global measures of brain change. Reduced activation of prefrontal cortex during cognitive tasks. Reproduced fairly consistently in pet and fmri studies. Conclusions (only important slide to know, not slides before)
