BIOC 3300 Lecture 14: BIOC3300 Lecture 14
10 Mar 2017
School
Department
Course
Professor
Document Summary
Atherosclerosis progressive narrowing of large arteries through a process of intimal thickening and lipid accumulations: 30% of all deaths worldwide, treatment vs prevention. Normal vessel wall anatomy: endothelium, internal elastic lamina, external elastic lamina. Major risk factors: (cid:313) age, males, family history, genetic abnormalities, hypertension, smoking, diabetes, physical inactivity. Minor/uncertain factors: obesity, stress, homocysteine, alcohol, lipoprotein a, high carbohydrate diet. Type i/ii lesions (fatty streak: isolated macrophage foam cells, modest lipid accumulation, mostly intracellular, present in first decade of life clinically silent and may be reversible. Type iii lesion (intermediate: changes to contain small extracellular lipid pools, growth of lesion is mainly through further lipid accumulation, clinically silent. Type iv lesion (atheroma: progression to contain a core of extracellular lipid, growth is mainly through further lipid accumulation. Type v lesion (fibroatheroma: contains lipid core and fibrous cap, proliferation of smooth muscle and extensive collagen.
