BIOC 3300 Lecture Notes - Lecture 11: Phosphatidylglycerol, Cardiolipin, Glycerophospholipid
4 Apr 2016
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Document Summary
Glycerophospholipid, found as components of membranes: what is the branch point between the synthesis of. 3 carbon sugar phosphate that is acylated and has a nitrogen base added to it: what is the function. Phosphatidic acid: what is the reaction that adds the headgroup to the phospholipid? activation by ctp (at sn-3 position), releasing ppi (driving the reaction forward) and cmp, *in bacteria*,from cdp- diacylglycerol, what is added to create phosphatidylserine and. Pg3p: *g3p* is added: *in bacteria*, from cdp- diacylglycerol, what is added to create cardiolipin and phosphatidylethanolamine, what are the two strategies for generation of a phosphodiester linkage, how is phosphatidic acid synthesized from. Activation of glycerol or activation of head group acyl chains are added in two consecutive steps as thioesters from acp to generate phosphatidic acid. Cardiolipin: made from pg3p; hydrolysis of pi to make phosphatidylglycerol, then combination of 2x phosphatidylglycerol to make cardiolipin phosphatidylethanolamine: sythiesized form phosphatidylserine, decarboxylation to make phosphatidylethanolamine.
