BIOC 3400 Lecture Notes - Lecture 32: Exonic Splicing Enhancer, Alternative Splicing, Intron

• School: Dalhousie University
• Department: Biochem & Molecular Biology
• Course: BIOC 3400
• Professor: Liu Paul

Document Summary

Study online at quizlet. com/_1tmwrp: alternative splicing: - generates different proteins from the same pre-mrna; produces different forms of a protein from the same gene. : - cis elements are required for alternative splicing: * sr: splicing regulator: +ve regulating; if present, recognize weak splice sites and enhance splicing activity. Repressor present, hide a potential exon from splicing; Activator present, help spliceosome to recognize a potential intron; enhance the recognition of weak splice sites in exons; Result: exon -> intron: ribozyme: an rna molecule possessing enzymatic properties; a ribonucleic acid (rna) enzyme that catalyzes a chemical reaction. The ribozyme catalyses specific reactions in a similar way to that of protein enzymes: autocatalytic (intramolecular) endonucleolytic cleavage: - self-splicing introns (group i and group ii; cleavage and re-joining)