BIOC 4403 Lecture Notes - Lecture 5: Demethylase, Gametogenesis, Hydrolysis
23 Mar 2017
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Document Summary
Originally referred to any process that allowed a particular phenotypic state to be inherited without changes in the sequence of dna: was used to describe the poorly understood processes leading from fertilized zygote to organism. Changes in inheritance can be due to: covalent modification of the dna (methylations, modification of the proteinaceous scaffold of dna (histones, assembly of proteins or protein complexes on the dna )transcription factors) Epigenetics is an advanced biological system that selectively utilizes genomic information and is involved in various fundamental phenomena. Specifically, it puts emphasis on the regulation of gene expression, through dna methylation, chromatin, and post-translational modification of proteins like histones. Arrows indicate possible functional interactions between them. Dna hyper-methylation, histone hypoacetylation and inactive chromatin repress transcription. A transcriptionally active condition may encourage dna hypomethylation, histone hyperacetylation and active chromatin. A particular chromatin structure may be required for establishing dna methylation.
