BIOL 2020 Lecture Notes - Lecture 27: Calmodulin, Phos, Conformational Change
17 Apr 2018
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Pi derived second messengers: what cleaves pip2 is attached to pip2, cuts ester bond so you release the inositol ring. Ligand binds to receptor, receptor acts as a gef, exchange gdp for gtp: positions 4 and 5. Inositol 1,4,5-triphosphate (ip3: dag ----> protein kinase c (pkc) (dag partly activates pkc, need ip3 to finish the job, need help from ip3 to activate pkc. Ip3 goes to smooth er: smooth er is reservoir for calcium. Ip3 binds to receptor on membrane, calcium rushes out and fills the cytoplasm: calcium finishes the activation of pkc, pkc phosphorylates various targets for different cellular responses. Summary: this is how fly vision works, very fast refresh rate, specialized eyes, rely on this pathway, g protein - rhodopsin. Important to immune system, controlling cell growth, and development: cancer research! Calcium ions: ca++ channels: outside the cell there is 10000 more times calcium than the cytosol.
