MICI 3119 Lecture Notes - Lecture 3: Cell Envelope, Lipid Bilayer, Cell Membrane
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5 Feb 2018
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Outline: outer membrane, lps, porins, braun(cid:2)s lipoprotein, periplasm. Outer membrane (om: primarily functions as a permeability barrier - selective barrier. Om is not as permeable to hydrophobic molecules as the cytoplasmic membrane(cm) Allows passage of hydrophilic molecules through porins: confers negative charge on bacteria, phage receptors (o-antigen and ompa, has the typical appearance of a "unit membrane", i. e. , a lipid bilayer (-8 nm thick), and is composed of: Lipopolysaccharide (lps) found only in outer leaflet of om. Lipoprotein (braun"s,) which is also associated with the peptidoglycan. Lipopolysaccharides (lps: also referred to as endotoxin/pyogen. Lipid a contains toxic activity (minor: cytokine induction; major: hypotension, septic shock). Elicits strong immune responses in mammals: functions: Confers negative charges and repels hydrophobic molecules. Repels fat soluble molecules such as bile that the gal bladder secretes. O-specific polysaccharide (o- antigen: varies in length and composition. "head" composed of 2 molecules of n- acetylglucosamine phosphates joined by a.