NESC 3170 Lecture Notes - Lecture 1: Steroid Hormone Receptor, Autocrine Signalling, Tryptophan
17 Apr 2018
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Document Summary
Testing causal links: hormonally-dependent behaviours should disappear with hormone removal. Can be by removing the hormone, or block the receptors on the target cells: behaviours reappear when hormone levels are restored. Or if receptors are unblocked: hormone levels and behaviours should be correlated. In intake individuals, ie not manipulated or human with no illness. Behaviour may also be in uenced by other sources ie. aggression is in uenced by testosterone but also from seeing a competing male: albation & replacement. Four steps: gland is surgically removed, effects of removal are observed, hormone is replaced, effects of replacement is observed. Can also lesion (damage) a part of the brain that is targeted by the hormone. Testing: hard to do, cannot take blood and stick a tool in to measure the amount of hormone in the sample. Especially hard with a new hormone: immunoassays. Detect chemical substances in bodily uid: competition for antibody binding. Ligand = something that binds to something else.
