NESC 3237 Lecture Notes - Nicotinic Acetylcholine Receptor, Vomiting, Behaviour Therapy

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Published on 17 Apr 2013
School
Dalhousie University
Department
Neuroscience
Course
NESC 3237
Professor
February 5th, 2013
February-05-13
2:30 PM
Self-administration in nonhumans
Recall that consumption is almost exclusively oral
o Because of this it can be hard to convince rodents to voluntarily drink alcohol
Pin-tailed shrew has had its body adapt in a way that makes it metabolize alcohol very quickly
because it eats a diet consisting mainly of fermented fruit
Hard to model in animals because they don't usually consume in the same pattern as humans
Self-administration in humans
Cultures can affect drinking tendencies
o More northern cultures have drinking habits that reflect that of binge drinking
Seems to be a very socially determined behaviour, especially in young people
Men tend to drink more than women
Age is a factor too, more socially accepted in younger people to binge drink
Behavioral economics of alcohol consumption
Consumption amounts related to the price
Relationship between the price of alcohol and death rate from liver cirrhosis
Alcoholism
Need a definition other than just the behaviour (drinks a lot, so is an alcoholic)
Definition needs to include
o Loss of control of your consumption
o A physical dependence
An idea that individuals can be born with alcoholism
o Have a predisposition for it even before drinking
o Described much like having an allergy
o Only moderate heritability has ever been shown though, never with any one specific gene
found as an absolute indicator
o Heritability depends on
Gender
Drinking behaviour
Definition of alcoholism
Adverse effects
Benzodiazapine can be very bad to mix with alcohol
Your body will reject alcohol before it can be absorbed into your system
o Vomiting
Hangover
o Most of the effects are associated with the activation of glutamate
Alcohol induced behaviours
o Negative consequences tend to be inhibited
o Majority of violent criminal offences occur when somebody has been consuming alcohol
Can cause cancer of the mouth, throat and liver
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Document Summary

Recall that consumption is almost exclusively oral: because of this it can be hard to convince rodents to voluntarily drink alcohol. Pin-tailed shrew has had its body adapt in a way that makes it metabolize alcohol very quickly because it eats a diet consisting mainly of fermented fruit. Hard to model in animals because they don"t usually consume in the same pattern as humans. Cultures can affect drinking tendencies: more northern cultures have drinking habits that reflect that of binge drinking. Seems to be a very socially determined behaviour, especially in young people. Men tend to drink more than women. Age is a factor too, more socially accepted in younger people to binge drink. Relationship between the price of alcohol and death rate from liver cirrhosis. Need a definition other than just the behaviour (drinks a lot, so is an alcoholic) Definition needs to include: loss of control of your consumption, a physical dependence.

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