NESC 3237 Lecture Notes - Opponent Process, Incentive Salience, Mesolimbic Pathway

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Published on 17 Apr 2013
School
Dalhousie University
Department
Neuroscience
Course
NESC 3237
Professor
January 22nd, 2013
January-22-13
2:33 PM
***Guest Lecture***
Marcel Peloquin - Addiction Lecture
What is addiction?
Addiction is a primary, chronic disease of brain reward, motivation, memory and related circuitry.
Dysfunction in these circuits leads to characteristic biological, psychological, social and spiritual
manifestations. This is reflected in an individual pathologically pursuing reward and/or relief by
substance use and other behaviours. Addiction is characterized by inability to consistently
abstain…..on slide
You can become addicted to
Alcohol
Tobacco
Opiates
What about
Cannabis
Gambling
Pornography
LSD
Coffee
Exercise
Using the internet
Working
Sex
4 main categories
Condition based-models
o Opponent-process model of addiction
Whenever you engage in a process (take heroin) you body produces a subsequent
action to bring your body back to a normal level
You get this rebound effect where you go below normal, kinda like an undershoot,
and eventually return to normal
Underlying opponent processes (opponent process theory)
A is the high you get from the drug
In this theory, this doesn't change
B is the subsequent action produced by your body
However this does get bigger the more you use it, so over time your
withdrawal gets stronger
Cognitive models
o Basic principles of this is that you have cravings and urges
Craving to use a drug
Urge to go out and physically use a drug
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Document Summary

Addiction is a primary, chronic disease of brain reward, motivation, memory and related circuitry. Dysfunction in these circuits leads to characteristic biological, psychological, social and spiritual manifestations. This is reflected in an individual pathologically pursuing reward and/or relief by substance use and other behaviours. Addiction is characterized by inability to consistently abstain on slide. Condition based-models: opponent-process model of addiction. Whenever you engage in a process (take heroin) you body produces a subsequent action to bring your body back to a normal level. You get this rebound effect where you go below normal, kinda like an undershoot, and eventually return to normal. A is the high you get from the drug. B is the subsequent action produced by your body. However this does get bigger the more you use it, so over time your withdrawal gets stronger. Cognitive models: basic principles of this is that you have cravings and urges. Positive affective urge network becomes more powerful over repeated use.

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