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NESC 3237 Lecture Notes - Sidestream Smoke, Nicotine Dependence, Tegmentum

Course Code
NESC 3237
Sean Barrett

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February 12, 2013
2:33 PM
For Exam
50 points for multiple choice
10 for 2 short answer questions
60 points total
Not really concerned with background info, statistical methods
More focused on the results and methods
Short answer from lecture material
Multiple choice based on articles
Probably around 2 questions per articles
For addiction pathways
o Mesolimbic dorsal striatum
o Frontal cortex
o Anything in particular mentioned, be sure to know really well
o Be familiar with neurochemistry involved with different addiction pathways
Tobacco is highly addictive
Tobacco addiction is arguably one of the most addictive drugs out there
Idea that tobacco addiction and nicotine addiction are synonymous
Tobacco related disorders
o Nicotine dependence
o Nicotine withdrawal
Why is the focus on nicotine
There is very little direct evidence that nicotine itself is an addictive drug
It's the most abundant component of tobacco
Has psychoactive properties
o Increase in heart rate, blood pressure
Nicotinic receptor sites on dopaminergic cells in the ventral tegmental area
What makes a substance addictive
It needs to be voluntarily administered
Must choose the substance over a pharmacologically inert substance
The drug itself must be capable of producing compulsive patterns of use
Removal of the substance must produce withdrawal
Will nicotine dependent humans self-administer nicotine
Independent of tobacco use
Studies have been conducted using different methods of administration and different types of
o The majority of these studies fail to develop a preference for nicotine in absence to tobacco
in comparison to a placebo
The only studies showing self-administered nicotine are the studies where participants are told
they will receive nicotine or inactive placebo
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