NESC 3237 Lecture Notes - Vasodilation, Methylphenidate, Nicotinic Acetylcholine Receptor
18 Apr 2013
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Very rapid tolerance seen in hallucinogenic drugs. If lsd taken again the next day, not very large effects seen: because of this, these drugs are not very likely to be compulsively used. Maximum effects obtained at very low doses (lsd in particular: once all receptor sites occupied, you may have longer duration of effects if you take more, but you will not have a greater high. Often just used for a period of a few years. Not usually self-administered by animals: because effects take so long to onset. Has characteristics of hallucinogenic drugs and has psychostimulant properties: so a cross from amphetamine and hallucinogen. Increased feeling of well being, heightened feeling of connectedness: connectedness from affect on oxytocin. Da, 5ht and ne agonist: a reuptake inhibitor, also facilitates release. Some evidence that there"s a risk of 5ht neurotoxicity associated with repeated use: depression, memory and attention problems, anxiety, impulsivity.
