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NESC 2570 (6)

March 22nd 2012.docx

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NESC 2570
Stefan Kreuger

March 22nd 2012 April-11-12 10:19 AM Somatosensory Receptors  Skin o Pancinian corpsucle  Very deep in the dermis, onion structure, dampens signal to nerve, detects vibration  Massively adapting, responds only at the onset of stimulation o Meissner's corpuscle  Just below epidermis, pressure, vibration, stretch (stroking) o Ruffini's corpuscle  Stretch o Merkel's disk  Pressure o Pree nerve endings  Pain and temperature  Nociceptors Hairy skin  Each hair has a hair receptor o Free nerve ending wrapped around follicle  Responds to stroking Trp channels for pancinian corpuscles  Non-selective cation channels  Are mechanosensitive  Involved in many things  Have a generator potential o Graded depolarization TrpA  Had a lot of anchorin o Have motor proteins attached o Bound to cytoskeleton  Movement makes opening of channel occur  Large anchorin domain, TrpC has small domain *voltage-gated calcium channels are mechanosensitive*  Not really, just work that way Most important mechanosensitive channels  In muscles o Proprioceptors  Have a very large, mylenated axon --> very fast response  Can tell how much muscle length has changed  Golgi tendon organs o At interface where muscle attaches to a tendon  Measure tension  Give rise to opposite pull on muscles C-fibres  Pain, temperature, itch o Slow conducting, small, unmylenated  Free nerve endings Trp Channels and temperature sensitivity  Look like voltage gated potassium channels  Different channels activated by hot/cold  Capsacian can cause response o Comes from hot peppers o Makes some trp channels open TrpV1  Activated by capsacian o Nonspecific cation channels Cochlea  Snail like structure  Transduction o Occurs on basilar membrane by hair cells  Hair cells attach to spiral ganglion  Tectorial membrane o Above basilar o Hair cells project up into it  Inner hair cells  Transduction of vibration for hearing  Outer hair cells  Are little motors that can move the tectorial membrane o Movement of the cillia back and forth are what cause signals to be sent  Cillia are exposed to high potassium fluid in scala media  Causes
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