Class Notes (836,563)
Canada (509,855)
NESC 2570 (6)
Lecture

March 22nd 2012.docx

3 Pages
57 Views
Unlock Document

Department
Neuroscience
Course
NESC 2570
Professor
Stefan Kreuger
Semester
Winter

Description
March 22nd 2012 April-11-12 10:19 AM Somatosensory Receptors  Skin o Pancinian corpsucle  Very deep in the dermis, onion structure, dampens signal to nerve, detects vibration  Massively adapting, responds only at the onset of stimulation o Meissner's corpuscle  Just below epidermis, pressure, vibration, stretch (stroking) o Ruffini's corpuscle  Stretch o Merkel's disk  Pressure o Pree nerve endings  Pain and temperature  Nociceptors Hairy skin  Each hair has a hair receptor o Free nerve ending wrapped around follicle  Responds to stroking Trp channels for pancinian corpuscles  Non-selective cation channels  Are mechanosensitive  Involved in many things  Have a generator potential o Graded depolarization TrpA  Had a lot of anchorin o Have motor proteins attached o Bound to cytoskeleton  Movement makes opening of channel occur  Large anchorin domain, TrpC has small domain *voltage-gated calcium channels are mechanosensitive*  Not really, just work that way Most important mechanosensitive channels  In muscles o Proprioceptors  Have a very large, mylenated axon --> very fast response  Can tell how much muscle length has changed  Golgi tendon organs o At interface where muscle attaches to a tendon  Measure tension  Give rise to opposite pull on muscles C-fibres  Pain, temperature, itch o Slow conducting, small, unmylenated  Free nerve endings Trp Channels and temperature sensitivity  Look like voltage gated potassium channels  Different channels activated by hot/cold  Capsacian can cause response o Comes from hot peppers o Makes some trp channels open TrpV1  Activated by capsacian o Nonspecific cation channels Cochlea  Snail like structure  Transduction o Occurs on basilar membrane by hair cells  Hair cells attach to spiral ganglion  Tectorial membrane o Above basilar o Hair cells project up into it  Inner hair cells  Transduction of vibration for hearing  Outer hair cells  Are little motors that can move the tectorial membrane o Movement of the cillia back and forth are what cause signals to be sent  Cillia are exposed to high potassium fluid in scala media  Causes
More Less

Related notes for NESC 2570

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit