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NESC 3227 (19)
Kim Good (19)

February 5th, 2013.docx

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Dalhousie University
NESC 3227
Kim Good

February 5th, 2013 February-05-13 1:04 PM H.M  Had both temporal lobes removed in order to control his epileptic seizures  Couldn't be controlled by nearly lethal doses of anti-epileptic drugs  Had anterograde amnesia as a result, as well as retrograde amnesia o Retrograde memories were preserved up until a certain time, but most of them had disappeared  So had global amnesia  Still had some of his temporal lobe remaining after the surgery o The important bits that were involved in memory and emotional processing had been removed H.M.s memory  The only person he can remember is his neurologist o Because he had very long history with him o Couldn't remember anyone else  Can't learn a maze learning task o Can't even remember trying to learn this from the day before Spared functions in H.M.  His intelligence o IQ of 117  Language ability didn't seem to be impaired  Spatial analysis  Memory was spared on some tasks o Span of attention, looking online, finding a phone number, remembering it, then dialing it. Or a block tapping span  As long as he uses rehearsal, he's able to keep it in mind o Procedural learning, such as the mirror drawing task  Shows normal improvement in this task, but he never remembers having done this before  Probably because his basal ganglia is still in tact Unilateral temporal lobectomy  Treatment for epilepsy  Selective amygdalohippocampectomy is now performed instead because it removes a smaller brain region (SAH)  Usually produce milder more material specific memory loss then do bilateral lesions Effects of unilateral temporal lobectomy on memory  Removal of the left usually has an effect on verbal memory  Removal of right usually impairs non-verbal learning o Delayed reproduction of the image copying task, like what we did in class McGlone, J.  Interested in looking at how people felt after temporal lobectomy  Developed a memory complaint questionnaire (MCQ)  Found that verbal memory decline occurred after left-sided resections  But subjectively found that patients had fewer memory complaints, and actually thought their memory was improving o Not the case objectively Pyriform cortex  Primary sensory area involved with olfaction  Left side temporal lobectomy seems to reduce olfactory sensory thresholds  Located very near to the entorhinal cortex (parahippocampal gyrus) **Start Chapter 16 - The Frontal Lobes** The frontal lobes  20% of the neocortex, but 1/3rd the weight of the entire brain  3 main areas o Motor (brodmann 4, precentral gyrus)  Control of fine movement  Topographical mapping o Premotor area (brodmann 6, 8 & 44)  Selects movements depending upon cue  Controls eye movements, frontal eye fields found here  Supplementary motor cortex (6)  Internally driven movements o Prefrontal cortex  Receives numerous projections from thalamic nuclei, specifically the dorsomedial nucleus of the thalamus  Subdivisions:  Dorsolateral  Orbitofrontal (10, 11, 13, 47)  Sits over top the eyes
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