Class Notes (811,225)
Canada (494,571)
NESC 3227 (19)
Kim Good (19)

March 14th, 2013.docx

3 Pages
Unlock Document

Dalhousie University
NESC 3227
Kim Good

March 14th, 2013 March-14-13 1:03 PM Effects of early diffuse brain injury  Model: whole brain radiation after resection of focal tumour in childhood  This method used to be the norm  However many problems with cognition post-treatment arose Progress in the past 20 years  Reduced the amount of radiation used without significantly causing an increase in mortality rate  Has caused a decrease in cognition problems post-treatment Lete effects of whole brain radiation  Whole brain with high exposure leads to worsened cognitive outcome in children Wechsler FSIQ  If the radiation was confined to only where the tumor was, the decline in FSIQ is less than whole- brain radiation patients How does radiation affect the brain  Not really sure, but white matter more sensitive than grey matter o Possibly because of damage to myelin membrane  Can cause the death of neurons Radiation in child's brain selectively affects white matter  Deterioration in FSIQ was correlated with volume of cerebral white matter in cross sectional and longitudinal examinations Changes in treatment approaches  Lower doses of radiation o Followup with chemo  Psychological management o Post radiation treatment involving cognitive remediation  Compensatory memory notebook  Pharmaceutical management o Ritalin and other drugs Childhood hemispherectomy for seizure control  Sometimes the seizures are generalized, but if an entire epileptogenic hemisphere is removed in childhood, this stops grand mal seizures  Hemispherectomy, includes cortex  Can result in an increased FSIQ scores and development of speech as the child ages Focal brain injury and plasticity  The kennard principle or sparing of function following acute brain lesions in infancy o Brain injury has milder and less sustained effects if acquired in childhood than adulthood  Recovery of speech after left hemisphere damage o Depends on location of early lesion in left hemisphere, and bilaterality of lesion Effects of acute, early (before 5 years), left lesion on language  No shift of speech if lesion was outside of traditional speech zones  Complete shift from left to right if lesion encompassed broca's and wernicke's  Partial shift if either broca's or wernicke's areas are lesioned  No development of speech: Vargha-Khadem case of bilateral lesions in speech and in sensory motor zones o In this case study, had brocas lesion in left, and sensory motor areas in the right, because there was no intact region in the right hemisphere to shift broca's function to Early lesions to orbital ventromedial pref
More Less

Related notes for NESC 3227

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.