NESC 3227 Lecture Notes - White Matter, Parasomnia, Migraine
17 Apr 2013
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Document Summary
Model: whole brain radiation after resection of focal tumour in childhood. This method used to be the norm. However many problems with cognition post-treatment arose. Reduced the amount of radiation used without significantly causing an increase in mortality rate. Has caused a decrease in cognition problems post-treatment. Whole brain with high exposure leads to worsened cognitive outcome in children. If the radiation was confined to only where the tumor was, the decline in fsiq is less than whole- brain radiation patients. Not really sure, but white matter more sensitive than grey matter: possibly because of damage to myelin membrane. Radiation in child"s brain selectively affects white matter. Deterioration in fsiq was correlated with volume of cerebral white matter in cross sectional and longitudinal examinations. Lower doses of radiation: followup with chemo. Psychological management: post radiation treatment involving cognitive remediation. Pharmaceutical management: ritalin and other drugs.
