NURS 2050 Lecture Notes - Distal Convoluted Tubule, Renal Artery Stenosis, Carbonic Anhydrase Inhibitor
11 Apr 2013
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Glomerulus- all small filtrates get filtered (except large proteins like albumin). Excreting water (prevents the passive reabsorption of water) Increased urine is directly related to nacl reabsorption it blocks. Block the most nacl reabsorption = most profound dieresis. Rationale: since at the end of the tubule, most is reabsorbed, if you catch it earlier, you will block more. Diuretics at the end have the least impact. Greatest impact are the ones that work at the proximal tubule (osmotic diuretics= rarely used). *** but loop diuretics are the most effective (high ceiling) Drug excretion: by the kidneys via: glomerular filtration: (all small molecules go through here, no pumps/passive process) Nonselective process large molecules remain in the blood (proteins/lipids: active tubular secretion and/or reabsorption **active processes. Proximal convoluted tubule, loop of henle, distal convoluted tubule. Most diuretics act to inhibit this process! Greater than 99% of the filtrate undergoes reabsorption. Reabsorption is an active process (water is passive)
