PATH 3000 Lecture Notes - Lecture 14: Acute Respiratory Distress Syndrome, Disseminated Intravascular Coagulation, Myocardial Infarction
22 Feb 2020
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Path 3000 lecture 14 february 10, 2020 fluid and hemodynamic disorders ii. Objectives: understand hemostasis (clotting of blood), endothelial cells, platelets, coagulation cascade proteins: thrombin and fibrin, understand causes of pathologic thrombi, endothelial cell injury, decreased/altered blood flow, understand arterial thrombi: Intravascular coagulation: three principal components, coagulation factors (proteins produced in the liver) lead to fibrin production (meshwork, platelets part of clot, endothelial cells activate clotting cascade when damaged. When endothelial cells are damaged, they triggered the coagulation cascade that produces fibrin and activate platelets. At the top, there is a vessel defect in the endothelial lining. When the region underneath the damage is exposed to blood, there results in a rapid formation of a clot. There is conversion of prothrombin to thrombin, which converts fibrinogen into fibrin. Fibrinogen are zymogens, which are the inactivated form of precursors in the body.
