PATH 3000 Lecture Notes - Lecture 24: Myocyte, Skeletal Muscle, Epimysium

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Path 3000 lecture 24 march 13, 2020 pns pathology. Normal anatomy and physiology: skeletal muscle: composed of striated muscle fibers, connective tissue fascia, epimysium, perimysium, endomysium. A muscle is surrounded by the epimysium, which is made up of fascia, a sheath of connective tissues. The perimysium breaks the muscle up into individual bundles and is where the vascular supplies are. The connective tissues between individual muscle fibers is called the endomysium. Muscle cells: post-mitotic cells, with reserve cells capable of regeneration, specialized cells, rich in contractile proteins (actin, myosin, high ratio of cytoplasm to nuclei, nuclei beneath cell membrane. There are nuclei at the edge of muscle fibers and may be able to regenerate for healing and repair. Neuromuscular junction (nmj: site of contact between motor neuron axon terminal and muscle fiber, presynaptic terminal releases acetylcholine (ach, binds to ach receptor, depolarizes muscle, enzyme cholinesterase breaks the ach down.

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