PHAC 4001 Lecture Notes - Lecture 11: Pharmaceutical Drug, Drug Interaction, Pharmacodynamics
Phac 4001 lecture 11 february 1, 2021 drug interactions. Drug interaction definition: the administration of one agent that modifies the effect of a drug, the agent can be, a pharmaceutical drug, a recreational drug, an environmental toxin, food, herbals. Drug interaction prevention: understand drug mechanism, pharmacodynamics (target, pathway, and effect, pharmacokinetics (adme, monitor blood levels of drugs with narrow therapeutic windows, monitor parameters that may help characterize the early events of an interaction or toxicity. Pharmacodynamic interactions are important to understand because it is essential for us to know how these drug interactions happen at different levels. Drug a is binding to receptor 1 on the cell surface, that receptor is then activating kinase 1, which promotes the expression of gene x via phosphorylation. Drug b may target the same receptor, receptor 1, or it may target a different receptor, receptor 2.