PHAC 4001 Lecture Notes - Lecture 12: Inflammatory Bowel Disease, Rheumatoid Arthritis, Human Microbiota
12 May 2021
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Phac 4001 lecture 12 february 8, 2020 microbiome drug interactions. Involves the interaction between the microbes, environment, and genetics. Human microbiome: entire community of microbes (and their genes) that live in and on the human body, same number of microbial cells and human cells in the body, bacterial genes outnumber human genes ~100:1. Inflammatory bowel disease: obesity, cancer, atherosclerosis, autism, multiple sclerosis. In traditional microbiology, if we are interested in studying the microbiome in a stool sample, we would have to grow that multi-species samples and grow it over time to isolate a single species so we can study it. The problem with just studying a single species at a time is that you do not get the full picture of the effects of community interaction. It is also really hard to culture all the species from a specimen. The sample is taken from the specimen and the entire community is analyzed using dna sequencing.
