PHAC 4001 Lecture Notes - Lecture 24: Metastasis, Oxymetholone, Buserelin
12 May 2021
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Phac 4001 lecture 24 march 17, 2021 pituitary and gonadal hormones iii. Overview: brief review of the structure and function of the testis, feedback regulation, the hypothalamic-pituitary-testes axis, biosynthesis of testosterone and physiological roles, androgens, clinical uses and anabolic steroids, androgen replacement and suppression therapies. The testis: gametogenic and endocrine functions, the diagram on the right shows two large, columnar sertoli cells with their surfaces binding many germ cells in various stages of spermatogenesis. Within the seminiferous tubules, this is where the hypothalamic-pituitary-gonadal axis is working. The diagram on the right shows the basement membrane on the top and the lumen of the seminiferous tubules on the bottom. Inside the seminiferous tubules, there are columnar cells called sertoli cells. In the interstitial space are interstitial cells called leydig cells. Spermatogonia are attached to the basement membrane but are embedded in between sertoli cells. Thus, sertoli cells are also called nurse cells because they provide nutrients for spermatogenesis.
