PHAC 4001 Lecture Notes - Lecture 21: Insulin Glargine, Nph Insulin, Gliflozin

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Phac 4001 lecture 21 march 8, 2021 therapeutic approaches to diabetes ii. Therapeutic lifestyle changes for diabetes: can be useful for addressing primary causes (ex. Increased physical activity: 2-1/2 hours of moderate intensity or 1-1/4 hours of high intensity exercise per week, diet modification, overall reduction in caloric intake, especially fats and refined carbohydrates. Increased intake of fruits, vegetables, whole grains and dietary fibre: weight reduction, gradual loss (5-10% of body mass per year) is generally preferred. Ideally bmi < 24. 9: all degrees of weight loss are beneficial. In severe cases, bariatric surgery (reduces stomach size) or pharmacological agent (orlistat; reduces fat absorption but no well tolerated to adverse effects) may be prescribed. Insulin and insulin analogues: regular insulin, insulin ispro, nph insulin, insulin glargine. Insulin secretagogues: glyburide (sulfonylurea), rapaglinide (meglitinide: metformin, gliflozins: dapagliflozin, canagliflozin (sglt2 inhibitors, thiazolidinediones: avandia (rosiglitazone), actos (pioglitazone) Incretin agents: sitagliptin (dppiv inhibitor), exenatide (incretin mimetic)

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