PHAC 4001 Lecture Notes - Lecture 19: Lipodystrophy, Insulin Receptor, Cardiovascular Disease
12 May 2021
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Phac 4001 lecture 19 march 3, 2021 nuclear receptors: relation of drug metabolism and. Part ii - nuclear receptors as therapeutic drug targets: obesity, diabetes and cardiovascular disease, peroxisome proliferator-activated receptor- , thiazolidinediones. Lipodystrophy and obesity: heterogeneous disorders, abnormal adipose tissue mass and function. Influenced by genetics, environment, behaviour: lipodystrophy: little adipose tissue mass; obesity: significant adipose tissue mass. Increased risk for various metabolic, reproductive, hormonal, and developmental disorders: both disorders are susceptible to insulin resistance in the tissues. Obesity: excess body fat (adiposity, commonly defined by body mass index (bmi = weight in kilograms/the square of height in meters) 55 74 kg (121 163 lb) 75 89 kg (164 196 lb) Statistics canada compared the evolution of the modern canadian over a 30-years period from. Over the 30-year period, the average male body weight has gone up by about 20 pounds. Bmi has gone from the lower margin of the overweight range to inching towards the obese range.
