PSYO 3970 Lecture Notes - Lecture 1: Dnmt3B, Central Dogma Of Molecular Biology, Dna Replication
6 Sep 2018
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The molecular bases of inheritance central dogma of molecular biology = dna rna proteins. Steps: replication (in the nucleous, transcription (in the nucleous, translation (in the cytoplasm) Compositions of dna"s parts = one phosphate group + sugar base + nitrous group. Types of dna parts: guanine/adenine (purines, thymine/cytosine (pyrimidines) Neuron"s dna: heterochromatin: density packed together (genes); for genes that require activation to be expressed, euchromatine: loosed genes; these genes are constantly being expressed. Dna modification: dna methylation and hydromethylation (addition of methyl groups) cystosine methylcytosine; done by dnmt2, dnmt3a, dnmt3b. Methylcytosine hydroxymethylcytosine (associated with active transcription); done by. If cpg islands are methyladed is related with the transcription silencing. Cpg islands are usually unmethylated: histone ptms (post-translation modification) can be reversed, facilitates translation. By: 1) enzymes: hats/hdacs: proteins: histon methyltrasnferases and histone demethylases. Rna is prone to degradation because it is single stranded. Also its single stranded composition is the reason why rna is the information carrier.
