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Tight Junctions, Adheren Junctions, Desmosomes, Hemidesmosomes and Gap Junctions.docx

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BIOL 1215

Tight Junctions, Adheren Junctions, Desmosomes, Hemidesmosomes and Gap Junctions 1. Tight Junctions- consist of web-like strands of transmembrane proteins that fuse outer surfaces of adjacent plasma membrane together to seal off passageways between adjacent cells. -Common in epithelial tissues of the stomach, intestines, and urinary bladder that have many tight junctions to help to retard the passage of substances between cells and prevent contents in organ from leaking into the blood or surrounding tissues 2. Adherens Junctions- contain a dense layer of proteins on inside of plasma membrane called plaque that attach to membrane protein called and microfilaments of cytoskeleton. Transmembrane glycoprotein called cadherins join cells. Each cadherin inserts into plaque from opposite side of plasma membrane, partially crosses intercellular space (space between cells), and connects to cadherins of adjacent cells. In epithelial cells, adherens junctions form extensive zones called adhesion belts because they encircle cells. Adhesion junctions help epithelial surfaces resist separation during contractile activities (food moves through intestines) 3. Desmosomes- Contain plaque and cadherins that extends into the intercellular space between adjacent membranes and attach cel
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