PHED-4547EL Lecture Notes - Lecture 5: Innate Immune System, Mast Cell, Blood Vessel
27 Apr 2020
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Document Summary
Human body is the host: two approaches to respond to cell injury. Innate immunity: quick response to invading pathogens (disease-causing micro-organisms) or cellular injury, pathogen-associated molecular patterns (pamps, damage-associated molecular patterns (damps, pre-determined array of signals, limited to pamps and damps that have occurred during humane evolution. Injury related signals detected by pattern or pathogen. Recognition receptors: receptors on cells that can recognize disease-causing. Adaptive immunity organisms: slow but can adapt to changes, deals with challenges that were previously encountered by organism. Immune memory; response improves each time organism encounters the antigen: prrs different than for innate immunity, variable regions to adapt and fit injurious substance. Part of the innate immune response to agents that cause cell injury: physical, trauma, heat, cold, chemical, caustic or irritating chemicals, microbiological, bacterium or virus, parasitic organism. Mostly local reaction but could also be systemic. Non-specific, stereotyped response: doesn"t differ with respect to injury (from a tissue perspective)
