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Lecture 7

ANTH-110 Lecture Notes - Lecture 7: Insomnia, 5-Ht2C Receptor, Topiramate

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The hCG Diet
Human chorionic gonadotropin is a hormone produced during pregnancy. This new diet
plan claims that HCG can suppress appetite. The FDA, however, has not approved HCG
for weight loss, and it must be prescribed by a physician. Over-the-counter preparations
are often labeled as "homeopathic" but contain very little, if any, of the actual hormone.
People lose weight on this diet because the plan calls for a restriction of calories to 500
per day. This is not healthy, and one is likely to regain any weight lost during the severe
calorie restriction.
Medications and Surgery
For people who are overweight and have been unable to lose weight with diet and
exercise, consulting a weight-loss clinic may help. There are several prescription diet
pills that are now available.
Sibutramine (Meridia) is a prescription medication approved by the U.S. Food
and Drug Administration (FDA) in 1996. It may be recommended for people who
are more than 30 pounds overweight. In clinical trials, people who took this drug
lost an average of 5%-10% of their body weight. It may also help to keep weight
off. It works by making the person feel full and thereby decreases food intake. It
may cause an increase in blood pressure and should not be used by people who
are on a number of other medications, such as antidepressants.
Orlistat (Xenical 120 mg by prescription or Alli 60 mg available over the
counter) is a medication approved by the FDA in 1999. Your doctor may prescribe
it if you weigh more than 30% over your healthy body weight or have a BMI
greater than 30. Over one year, people who followed a weight-
loss diet and took orlistat lost an average of 13.4 pounds, almost 8 pounds more than
people who used diet alone to lose weight. It works by reducing the absorption of fat
from the intestine. Diarrhea and incontinence of stood may be side effects of this
Lorcaserin (Belviq 10 mg one to two times daily) was just approved by the FDA
in June 2012. It may be considered if your BMI is 30 or greater or if you have a
BMI greater than 27 with weight- related conditions. Studies demonstrated that
almost half of patients lost an average of 5% of their body weight when combined
with diet and exercise (compared to 25% of patients with diet and exercise alone).
Lorcaserin works by activating the serotonin 2C receptor in the brain, which helps
you feel full after smaller portions. The most common side effects were headache,
nausea, and dizziness.
Qsymia (combination of phentermine and topiramate) was just approved by the
FDA in July 2012. It is only approved for those with a BMI greater than 27 with
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