BIOL 200 Lecture Notes - Lecture 6: Chemical Bond, Peptide, Pharmacology
28 Mar 2013
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Document Summary
S1 is a polypeptide, p1 and p2 are products. The rst chemical step (3) includes the formation of a covalent acyl-enzyme intermediate. The second step (4) is the deacylation step. According to the proposed concept, the h transport from the enzyme promotes the. Rst reactant conversion, breakdown of the rst initial chemical bond (between groups p1 and. The step of hydrolysis leads to a breakdown of the second chemical bond and regeneration of the enzyme. the proposed chemical mechanism does not depend on the concentration of the substrates or products in the medium. This approach is in accordance with the following mechanism of muscle contraction. The nal step of atp hydrolysis in skeletal muscle is the product release caused by the association of myosin heads with actin. The closing of the actin-binding cleft during the association reaction is structurally coupled with the opening of the nucleotide-binding pocket on the myosin active site.
