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Lecture

BIOL 200 Lecture Notes - Ribose, Phosphodiester Bond, Pentose


Department
Biology (Sci)
Course Code
BIOL 200
Professor
Richard Roy

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BIOL200 Lecture 1 - Sept. 7
Introduction:
Central Dogma of Biology
DNA (Transcription) RNA (Translation) Protein
Nucleotides are the building blocks of nucleic acids
RNA = ribonucleic acid (<100 to 1000s of nucleotides long)
DNA = deoxyribonucleic acid (as long as several hundreds of millions of nucleotides long)
Nucleotide Monomers:
Phosphate group provides acidic character. Under intracellular conditions, the phosphate group is
negatively charged
Phosphate group linked by a phosphoester bond to a pentose (five carbon) sugar molecule
Difference between ‘Ribose’ and ‘2-Deoxyribose’ lies in one hydroxide group (OH vs. H)
Pentose is linked to a nitrogen- and carbon- containing ring structure referred to as a base
Purines are seen with a fused ring while pyrimidines do not have a fused ring
RNA has Uracil (U) as a pyrimidines instead of Thymine (T) which is used in DNA
Nucleosides are sugar and base without phosphate group
Amino acids are the building blocks of polypeptides
Proteins are like the cell muscles which provides various functions
Catalysis: catalyze intra- and extracellular chemical reactions
Structural: structural rigidity
Transport: flow of materials across membrane
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