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Lecture

mobile dna elements - comparison table


Department
Biology (Sci)
Course Code
BIOL 200
Professor
Mathieu Roy

Page:
of 2
Nuclear Eukaryotic DNA - in the human genome
1. protein coding genes
2. tandemly repeated genes
3. repetitious DNA - interspersed repeats (mobile DNA elements)
4. unclassified spacer DNA
length
copy
number
% of
genome
transposition mechanism
DNA transposons
a. terminal inverted repeat (TIR)
b. target site direct repeats/
duplication (TSD)
2 - 3 kb
300,000
3
- excise from donor DNA, inserted into target
DNA
- introns conserved
LTR retrotransposons
long terminal repeat
6 - 11 kb
440,000
8
- uses RNA polymerase II as an intermediate
introns removed during transcription
- retrotransposons remains in donor DNA
non-LTR retrotransposons
a. LINE’s
b. SINE’s
6 - 8 kb
100 - 400 kb
860,000
1,600,000
21
13
- LINE RNA is inserted into target DNA
- reverse transcription occurs
- RNA replaced by DNA
- utilize enzymes encoded by LINEs and host
genes for mobility
processed pseudogenes
variable
1 - 100
0.4