BIOL 200 Lecture Notes - Lecture 25: Aminoacyl-Trna, Start Codon, Transfer Rna

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8 Jun 2016
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How is the information content in dna transcribed to produced rna: genetic code: speci es which amino acids will be used to build a protein, codon: a sequence of three bases. Each codon speci es a particular amino acid: start codon: aug - initiation signal for translation (translational start site, stop codons: stop translation and polypeptide is released (translational termination signal) The three roles of rna in protein synthesis: class i rrnas - build the ribosomes, class ii mrnas - carries the protein encoding info, class iii trnas - bring in amino acids. All critical for making a protein trna. Pre-trnas are transcribed by rna pol iii and thereafter are processed to yield mature trna: 1. The 5" end sequence is removed: 2. A short segment within trna is removed: 3. Cca (tri nucleotide) is added on to the 3" end: 4. Chemical modi cations throughout - changing bases to less standard bases.

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