BIOL 200 Lecture Notes - Lecture 36: Granulocyte Macrophage Colony-Stimulating Factor, Wobble Base Pair, Elongation Factor
Document Summary
Alternative splicing controls sex determination in drosophila (cid:120) mixing and matching of exons (cid:120) clear differences between male and female flies (cid:120) there is clear sexual dimorphism which is a reflection of the chromosome content = dosage compensation. It makes changes by interacting with specific regions of pre-mrnas. Later in development, the female-specific promoter is repressed and a different sxl promoter is activated that is on in both sexes (cid:120) however, sxl pre-mrna is alternatively spliced dependent upon the presence of sxl protein. In a male, a different male-specific sexual dimorphic repertoire is activate: end up differentiating male flies from female flies. How does sxl protein regulate splicing? (cid:120) (cid:454)l (cid:271)i(cid:374)ds to a se(cid:395)ue(cid:374)(cid:272)e (cid:374)ea(cid:396) the (cid:1007)" e(cid:374)d of the i(cid:374)t(cid:396)o(cid:374) (cid:271)et(cid:449)ee(cid:374) e(cid:454)o(cid:374)s (cid:1006) a(cid:374)d (cid:1007) a(cid:374)d (cid:271)lo(cid:272)ks the association between. Thus exon 2 gets spliced to exon 4 and exon 3 goes out as part of a larger intron.
