BIOL 200 Lecture 39: 39

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14 Jun 2016
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Mechanism for nuclear import of nls-containing cargo proteins (cid:120) the(cid:396)e"s a (cid:272)o(cid:374)(cid:272)e(cid:374)t(cid:396)atio(cid:374) g(cid:396)adie(cid:374)t (cid:271)et(cid:449)ee(cid:374) ra(cid:374) gdp a(cid:374)d its gtp (cid:271)ou(cid:374)d state: the(cid:396)e"s (cid:448)e(cid:396)(cid:455) little ra(cid:374) gdp i(cid:374) the nucleus, through a concentration gradient, ran. Some rnas are exported through associating with ran (cid:120) exportin t functions to export trnas. It binds fully processed trnas and ran-gtp and passes through npcs. Model of mrnp export (cid:120) mrna exporter with the two subunits are bound to the sr proteins on the mature mrna and they follow the arrow into the cytoplasm. Insect polytene chromosomes provide a system where transcription and mrnp export can be microscopically imaged (cid:120) si(cid:374)(cid:272)e (cid:396)i(cid:271)oso(cid:373)es asso(cid:272)iate (cid:449)ith the (cid:373)rna (cid:449)hile it is still (cid:271)ei(cid:374)g e(cid:454)po(cid:396)ted, the (cid:1009)" e(cid:374)d (cid:373)ust (cid:271)e e(cid:454)po(cid:396)ted fi(cid:396)st. How is the information content in dna transcribed to produce rna? (cid:120) genetic code: specifies which amino acids will be used to build a protein (cid:120) codon: a sequence of three bases.

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