BIOL 200 Lecture Notes - Lecture 46: Phosphodiester Bond, Ribonuclease Iii, Rap1
Document Summary
(cid:120) ferritin is an intracellular protein that binds iron ions, thereby preventing the accumulation of toxic levels of free iron ions (cid:120) under high iron concentrations, you want to make enough. Ferritin to titrate iron so it (cid:449)o(cid:374)"t (cid:271)e to(cid:454)i(cid:272) to the (cid:272)ell (cid:120) mrna is translated and you make a nice amount of ferritin protein (cid:120) In the low iron induced concentrations, ire-bp (cid:272)a(cid:374) (cid:271)i(cid:374)d to the ires i(cid:374) the (cid:1009)" utr of fe(cid:396)(cid:396)iti(cid:374) (cid:373)rna, i(cid:374)hibiting translation of the mrna. Post-translational regulation (cid:120) protein modification: phosphorylation (cid:131) on specific protein targets, can give rise to certain functions, glycosylation (cid:131) modify protein in er, lipid moieties (cid:131) functional groups with lipids in them (cid:131) Lipids important for overall activity of proteins: methylation/acetylation (cid:120) protein stability, ubiquitin-mediated proteolysis (cid:131) addition of small polypeptides to proteins in a regulated manner (cid:131) ca(cid:374) (cid:272)ha(cid:374)ge a p(cid:396)otei(cid:374)"s fate e(cid:374)ti(cid:396)el(cid:455, proteasome.
