BIOL 201 Lecture Notes - Lecture 22: Sponge, Cell Adhesion Molecule, Cell Adhesion
11 Apr 2018
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Cells interact with and receive signals from the environment. Chemical signals: ex: cells in the intestines are connected to each other and to the basal lamina, ex: neurons trigger changes by releasing neurotransmitters. Cells can adhere to each other and to their surroundings. 2 classes: cell-cell adhesion: cell adhesion molecules (cams, cell-matrix adhesions (let"s call them mams) We need a large variety of adhesion molecules to stick to certain areas and not to other high gene diversity: ex: Dimers of and subunits interacting which each other creates even more diversity within the class. We will look at cadherins (cam) and integrins (mam): basic idea: Create cell adhesion by adding many weak adhesions to a large adhesion. Cis-oligomerization of cadherin (dimers are formed with the cadherins on the same membranes. Cis-oligomers bind in trans to other cadherins oligomers on other cells: like velcro. Cell-cell adhesions allow different cell types to cluster.
