BIOL 201 Lecture Notes - Rho Family Of Gtpases, Cdc42, Cyclic Adenosine Monophosphate
8 May 2012
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Document Summary
Stress fibres are actin bundles that can contract and produce force. Integrins are a component of focal adhesion, part that contacts extracellular matrix. Actin filaments are organized in contractile bundles (ability to get shorter and when contract, generate force that pulls cell forward) The blue structures that are not labelled and made up of myosin protein which is capable of producing force (pushing and pulling). Myosin has a nucleotide binding site (atp) and actin binding site. It converts chemical energy from atp and translate it into mechanical work. Motor proteins that convert chemical energy in the form of atp into mechanical work. Motor proteins are able to convert 65% of the chemical energy found in atp into mechanical work. Myosin motor domain, head domain has binding pocket for atp, binds to actin filament and undergoes large conformational change which the release of phosphate after hydrolyzes atp and conformational change exerts pull. Non-muscle myosin-ii forms bundles that pull actin filaments inward.
