BIOL 300 Lecture Notes - Lecture 16: The Selector, Exon, Alternative Splicing
15 Dec 2012
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Document Summary
As we said before, tra is an activator protein. The most complicated example is mutually exclusive splicing; an example could be found in muscle cells in the zasp52 gene which is responsible for proper muscle contraction. The zasp52 gene has many isoforms, there were at least 13 identified, all containing the result of a mutually exclusive splicing even between exons 7 and 8; these isoforms either have exon 7 or exon 8, but not both. Yet another mechanism is called spliceosome incompatibility, which occurs for example in the human. Jnk1 gene, which encodes a kinase: contained in these exons are binding sites for special. Snrnps known as u11, related to u2, and u12, related to u2. Syndrome cell adhesion molecule (dscam) gene which is located on chromosome 21. Down syndrome is a mental impairment disease caused by contained 3 copies of chromosome 21. This does not work through any of the previous mechanisms we have mentioned before.
