BIOL 300 Lecture Notes - Janus Kinase 2, Signal Transduction, Alanine
15 Dec 2012
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Document Summary
Cytokine receptors control differentiation of many cell types: Stat is also able to be phosphorylated by other kinases, but this is the most common way. We can see that the epor mutant lacks all red blood cells (there is no red in the embryo); similarly, a. Jak2 kinase null mutant would not be able to produce rbcs: these embryos are obviously non-viable. Inhibitory smads (i-smads) cause inhibition of the pathway by binding active ri and preventing binding of. R-smads to prevent continuation of the pathway: this is a negative feedback mechanism, because the i-smad gene is one of the genes activated by this pathway (i. e. the pathway produces its own inhibitory component) Usually, a cell has to respond to a combination of signals at the same time; every cell need at least a few pathways to just survive, and even more if it wants to grow or.
