BIOL 300 Lecture Notes - Growth Factor, Proteoglycan, Platelet-Derived Growth Factor

• School: McGill University
• Department: Biology (Sci)
• Course: BIOL 300
• Professor: Siegfried Hekimi

Document Summary

Enzyme-linked receptors are typically linked to slow transcriptional responses: growth, proliferation, differentiation and survival. Shock: the enzyme involved with these receptors are usually kinases, and involve mainly paracrine signaling. Gprc mutations cause mainly mental diseases (they"re involved mainly in neural transmission) while enzyme-linked receptor mutation can lead to cancer. Gpcrs shift the orientation of their tm helices (as we saw before), but how does this work for kinase receptors, which only have one tm helix. All receptors with only 1 tm domain must dimerize in order to activate; they are inactive in their monomeric state, and binding of the ligand causes activation through dimerization: there are different methods of dimerization. The pdgf receptor binds pdgf as its ligand; each adjacent receptor binds 1 ligand, and the ligand itself acts as a bridge to form the dimer. For the fgf receptor, the ligand binding to the receptor allows binding to a large membrane component known as a proteoglycan.