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ANAT 212 (5)


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Anatomy & Cell Biology
ANAT 212
Jason Young

targeting signal signal recognition membrane transport (how?) (where? how?) -SRP binds signal sequence and -ribosomes transfers frin SRP-SR complex to the -signal peptide: hydrophobic central ribosome during translocon, GTP hydrolysis by SRP & SR , dissociate and ER translocation region (6 aa) with short polar sides translocation recycle them, Translation –translocated into ER lumen, -mostly, at N-terminus, cleaved off after translocation, shorter hydrophobic -SR binds SRP energy of peptidyl-transferase (Sec61 translocon-when no complex-ribosome protein inactive and plugged, open laterally) -Sec61 translocon -signal sequence in different place, ER translocation, another hydrophobic become TM helice, with TM helix longer hydrophobic region Same as above Same as above -Type 1 TM domain=N-terminus lumenal/extracellular -TM comes from ribosome and dissociates from it Tail Anchor -C-terminal (in lumen) Type 2 TM , N- BAT3 -BAT3 transfer TM sequence to TRC40 targeting terminus in cytsol complex, ATP bounds state with polypeptide docks onto GET1/2 , hydrolysis release on membrane -TM proteins have exit signals on cytosolic side SAR1, Sec23/24 Adaptors acts as GAP, that allows Sar1 to hydrolyze GTP, ER exit -di-phenylalanine (FF) at C-terminus adaptor SAR-GDP release from vessicle membrane, adaptors -Coat (Sec 13/31) separate from SAR1 and coat separate from adaptors -Asp-X-Glu (DXE) within a sequence
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