ANAT 261 Lecture Notes - Lecture 2: Cell Junction, Tight Junction Protein 1, Tight Junction
23 Nov 2017
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Document Summary
In the picture on the right are two cells packed tightly together (b/c they are epithelial cells) Circled in red is the zonula occludens (tight junction) Zonula occludens tight junctions: membrane proteins make up tight junctions, membrane proteins: occludin, claudin, cytoplasmic proteins: zo-1, actin, blank. Gap junctions intracellular junctions that hold cells together. Belt around the cell called the terminal bell of actin. There are proteins that hold/stick the cells together. Desmosomes are there to hold the cells together. Most important junction because liquids can pass through cells without them. There are membrane proteins that make up a tight junction: occludins, claudins. Cytoplasmic proteins: zo-1, actin (cytoskeletal filament, has polarity and gives a cell its structure) Two vertical lines are the two different cell membranes that are interlinked by the membrane proteins. The protein tails will link to a zo-1 protein, which will connect to actin filaments. The actin filaments will bind across the cell and produce a terminal web.
