ANAT 262 Lecture Notes - Xpo1, Pex5, Peroxin-7

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plumcod665

21 Aug 2012

School

McGill University

Department

Anatomy & Cell Biology

Course

ANAT 262

Professor

John Presley

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Document Summary

Direction of rna transport all have trafficking aided by transporters. Mrna will not be exported if it is not spliced (also needs 5" cap and 3" poly a tail but those are less important) Transcript in nucleus contains introns which have nuclear retention signal so un- til splice they will not be shuttled to the cytoplasm. Virus has an rre which rev binds to (rev contains a nuclear export signal) so if. Crm1 binds to rev we have nuclear export. Rev protein binds to rre which has hydrophobic export signal which is recog- nized by crm1. Drug lmb interferes with crm1 functioning and causes disappearance of virus but cells die as it is not specific and prevents export of other important molecules. Creating mutant rev with non-working nes would prevent export. Looking for drug to prevent rev binding to rre. Ddx19 is the human version of dbp5p which needs to be on rna for tap to export it.

Related Questions

Cyclin B1, a key cell cycle regulatory protein in vertebrates, is mostly cytosolic before mitosis. Early in mitosis, however, the protein is phosphorylated by certain protein kinases and consequently accumulates in the nucleus. How can phosphorylation bring about nuclear accumulation of this protein?

A. Phosphorylation within the nuclear localization signal inhibits the function of the signal.

B. Phosphorylation within the nuclear export signal enhances the function of the signal.

C. Phosphorylation within the nuclear export signal interferes with the function of the signal.

D. Phosphorylation elsewhere on the protein enhances binding to cytosolic proteins

fuchsiasea-lion54

Recall how T-cells are able to control transcription by NF-AT by trafficking NF-AT into and out of the nucleus. In an activated, T-cell NF-AT enters the nucleus. As the T-cell becomes deactivated, most of the conditions below must be met for NF-AT to exit the nucleus. Which choice below is NOT a condition for its exit? A. NF-AT must be bound to the export receptor B. Calcineurin must be bound to NF-AT C. NF-AT must display a nuclear export sequence D. Ran-GTP must be bound to the export receptor

sangriadinosaur503

RNA polymerase continues transcribing until it receives a signal to stop. In prokaryotes, how does the protein Rho terminate transcription during Rho-dependent termination?

		Rho prevents nuclear export.
		Rho creates a hairpin loop in the RNA.
		Rho binds to a sequence in the RNA and then pushes RNA polymerase off the DNA.
		Rho cleaves the RNA and adds a polyA tail.

maroonwhale479

ANAT 262 Lecture Notes - Xpo1, Pex5, Peroxin-7

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