ANAT 262 Lecture Notes - Lecture 8: Tgm, Copii, Clathrin
30 Aug 2016
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Document Summary
Anterograde from tgm of golgi: clathrin coated vesicles & tubular transport intermediates. Enzymes compartmentalized, location in golgi dependent on function. Cargo receptors used when proteins to be transported do not have transmembrane domains. Kdel signal to bring back to er, recognized by kdel receptor. Receptor in membrane, act as transmembrane portion for soluble proteins, receptor recognized by cop. Copii recognize kkff (or ff w/kk close by) Ergic53 & p24 have kk & ff domains bring to golgi, back to er. Kdel receptor only has kk; reside in vtcs/cis-golgi bring er proteins back. Anterograde by copii, carries cargo & receptors (for soluble cargo) to golgi. Retrograde by copi, carries empty cargo receptors back to er. Not supposed to be recognized by copii, can sometimes leave by accident. Beta, gamma, delta, zeta homologous to ap1, parallel to adaptor proteins/inner subunit. Copii: inner subunit recognizes cargo, outer subunit curves membrane. Copi: outer subunit recognizes cargo & curves membrane.
